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noninvasive ecg recording platform  (Mouse Specifics)
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Mouse Specifics noninvasive ecg recording platform
Retrospective effect of ketogenic diet on heart rate. ( A ) Representative <t>electrocardiography</t> <t>(ECG)</t> traces depicting a normal rhythm and bradycardia. The red dot indicates ‘R’ in the QRS complex. Horizontal scale bar 0.2 s. ( B ) A histogram of the distribution of WT heart rate data. The mean and 2 standard deviations (2 SD) below the mean are indicated. Bradycardia was identified as a heart rate less than 2 SD, or 684 bpm. WT-SD and WT-KD heart rates did not differ ( p > 0.9 between groups, p > 0.9 at each timepoint) and were thus combined to determine bradycardia. ( C ) Heart rate data plotted retrospectively in days PTD. ( D ) Scatterplot of the mean heart rate for each segment from WT-SD (blue), KO-SD (red), WT-KD (black), and KO-KD (salmon) recordings. Segments with a mean rate of <684 are considered bradycardia and are highlighted in the shaded region. ( E ) The bradycardia fraction was determined for each subject (number of segments identified as bradycardia/total number of segments). Sample sizes = 6–7 mice for each genotype and each diet treatment. All values represent mean ± SEM. + p < 0.05, ++ p < 0.01 when comparing KO-SD vs. WT-SD. * p < 0.05, ** p < 0.01 when comparing KO-SD vs. KO-KD.
Noninvasive Ecg Recording Platform, supplied by Mouse Specifics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/noninvasive+ecg+recording+platform/pmc12986616-104-13-18?v=Mouse+Specifics
Average 86 stars, based on 1 article reviews
noninvasive ecg recording platform - by Bioz Stars, 2026-07
86/100 stars
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Retrospective effect of ketogenic diet on heart rate. ( A ) Representative electrocardiography (ECG) traces depicting a normal rhythm and bradycardia. The red dot indicates ‘R’ in the QRS complex. Horizontal scale bar 0.2 s. ( B ) A histogram of the distribution of WT heart rate data. The mean and 2 standard deviations (2 SD) below the mean are indicated. Bradycardia was identified as a heart rate less than 2 SD, or 684 bpm. WT-SD and WT-KD heart rates did not differ ( p > 0.9 between groups, p > 0.9 at each timepoint) and were thus combined to determine bradycardia. ( C ) Heart rate data plotted retrospectively in days PTD. ( D ) Scatterplot of the mean heart rate for each segment from WT-SD (blue), KO-SD (red), WT-KD (black), and KO-KD (salmon) recordings. Segments with a mean rate of <684 are considered bradycardia and are highlighted in the shaded region. ( E ) The bradycardia fraction was determined for each subject (number of segments identified as bradycardia/total number of segments). Sample sizes = 6–7 mice for each genotype and each diet treatment. All values represent mean ± SEM. + p < 0.05, ++ p < 0.01 when comparing KO-SD vs. WT-SD. * p < 0.05, ** p < 0.01 when comparing KO-SD vs. KO-KD.

Journal: Nutrients

Article Title: A Longitudinal Study of the Effects of Ketogenic Diet on Seizures, Cardiorespiration, Sleep Architecture and Mortality in the Kv1.1 Knockout Mouse Model of Sudden Unexpected Death in Epilepsy (SUDEP)

doi: 10.3390/nu18050809

Figure Lengend Snippet: Retrospective effect of ketogenic diet on heart rate. ( A ) Representative electrocardiography (ECG) traces depicting a normal rhythm and bradycardia. The red dot indicates ‘R’ in the QRS complex. Horizontal scale bar 0.2 s. ( B ) A histogram of the distribution of WT heart rate data. The mean and 2 standard deviations (2 SD) below the mean are indicated. Bradycardia was identified as a heart rate less than 2 SD, or 684 bpm. WT-SD and WT-KD heart rates did not differ ( p > 0.9 between groups, p > 0.9 at each timepoint) and were thus combined to determine bradycardia. ( C ) Heart rate data plotted retrospectively in days PTD. ( D ) Scatterplot of the mean heart rate for each segment from WT-SD (blue), KO-SD (red), WT-KD (black), and KO-KD (salmon) recordings. Segments with a mean rate of <684 are considered bradycardia and are highlighted in the shaded region. ( E ) The bradycardia fraction was determined for each subject (number of segments identified as bradycardia/total number of segments). Sample sizes = 6–7 mice for each genotype and each diet treatment. All values represent mean ± SEM. + p < 0.05, ++ p < 0.01 when comparing KO-SD vs. WT-SD. * p < 0.05, ** p < 0.01 when comparing KO-SD vs. KO-KD.

Article Snippet: To increase rigor, heart rate was recorded in non-anesthetized, conscious mice using a noninvasive ECG recording platform (ECGenie Mouse Specifics, Inc., Boston, MA, USA).

Techniques: